The Koren Lab

Systematic investigation of the specificity of degradation pathways with implication to human disease

Protein degradation plays a key role in nearly all cellular processes. A key to understanding how proteolysis is regulated is to decipher the specificity of substrate recognition. In the Koren lab, we apply genome wide proteomics and genetic approaches to obtain a global view on mammalian protein turnover networks. In particular, we study dedicated protein quality control pathways that monitor the proteome to preserve protein homeostasis and their perturbations in human disease.